Fragile x
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      1. Fragile X Knowledge Center
      2. Premutation
      3. Fragile x

      Are there individuals with the Fragile X premutation and are unaware of their genetic condition?

      Yes, Fragile X conditions are inherited genetically, and it is passed through generations often unknowingly.

      How many individuals are carriers of the FMR1 premutation?  According to a 2012 study by the CDC, the frequency of Fragile X premutation in the U.S. is as follows:

      • 1 in 151 females, or about 1 million women
      • 1 in 468 males, or about 320,000 men

      To find out more: