At what age do symptoms of Fragile X - associated tremor/ataxia syndrome (FXTAS) start appearing?

For men who are premutation carriers, the chance of developing core symptoms of FXTAS (tremor, problems with walking/balance) increases with age: 

  • Ages 50-59 the chance is about 17%. 
  • Ages 60-69 about 38%. 
  • Ages 70-79 about 47%. 
  • Over 80 years old, about 75% will develop symptoms of FXTAS. 

For women 8%-16% of women older than 40 years of age may develop FXTAS.

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