Premutation
      Back to home
      1. Fragile X Knowledge Center
      2. FXPOI
      3. Premutation

      What is the prevalence of Fragile X - associated primary ovarian insufficiency (FXPOI)?

      FXPOI occurs in about 20-25% of adult female FMR1 premutation carriers. It has also been reported in teenagers who are carriers, though it is less common in that population. 

      About 2% (1 in 50) of women with ovarian insufficiency are found to have an FMR1 premutation, as do about 7% (1 in 15) of those with a personal and family history of ovarian insufficiency.

      Learn more about FXPOI: