- Fragile X Knowledge Center
- Genetics
- Premutation
What are AGG interruptions?
A different DNA pattern called an AGG interruption, which occurs between about every nine or 10 CGGs. In the normal Fragile X gene (five to 45 repeats), you might have a 30-CGG-repeat pattern that has 10 CGGs, one AGG, then 10 CGGs, then one AGG, then another 10 CGGs. These AGG interruptions act as a sort of anchor, keeping the 30-repeat FMR1 gene stable, like fence posts every 10 feet in a long fence.
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