Premutation
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      1. Fragile X Knowledge Center
      2. FXPOI
      3. Premutation

      What are the signs and symptoms of somebody with Fragile X - associated primary ovarian insufficiency (FXPOI)?

      Common symptoms of FXPOI include:

      • Absent or irregular cycles
      • “Sub-fertility” or infertility
      • Hot flashes
      • Premature ovarian failure (POF), which is the complete cessation of menstrual periods before the age of 40.

      In the wider range of FXPOI symptoms, premature ovarian failure is at the more severe end of the spectrum. FMR1 premutation carriers can have normal ovarian function, but can still go through early menopause, which is menopause occurring between 40 and 45 years of age (menopause normally occurs between 45 and 55 years old). 

      For more information on the signs and symptoms of FXPOI: