Premutation
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      1. Fragile X Knowledge Center
      2. FXTAS
      3. Premutation

      I am a female with the Fragile X premutation, am I at risk for developing Fragile X - associated tremor/ataxia syndrome (FXTAS)?

      Studies of females have found that about 8-16% of premutation carriers, within families already known to have someone with a Fragile X condition, develop some FXTAS symptoms. The symptoms in females tend to be milder. Female premutation carriers can also be affected by Fragile X-associated primary ovarian insufficiency (FXPOI), another of the conditions associated with the change in the FMR1 gene.

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